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US 8,802,690 B2Granted
N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors
AssigneePfizer Inc.
InventorsScott William Bagley, David Andrew Griffith, Daniel Wei-Shung Kung
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Abstract
The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.
Claims4
A compound of Formula (I)
- wherein
- R1 is (C1-C6)alkyl, (C3-C7)cycloalkyl, tetrahydrofuranyl or oxetanyl;
- wherein said (C1-C6)alkyl is optionally substituted with (C1-C3)alkoxy, phenyl, or tetrahydrofuranyl;
- R2 is hydrogen, halo, (C1-C3)alkyl, or cyano;
- R3 are each independently hydrogen or (C1-C3)alkyl;
- R4 is naphthyl optionally substituted with one to four substituents independently selected from (C1-C3)alkyl, (C1-C3)alkoxy, halo, amino, (C1-C3)alkylamino, di(C1-C3)alkylamino, hydroxy, cyano, amido, phenyl, 5 to 6 membered heteroaryl or 5 to 6 membered heterocyclyl;
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.