US 8,802,688 B2Granted

Substituted acetyl-coa carboxylase inhibitors

AssigneePfizer Inc.

InventorsRobert Lee Dow, David James Edmonds, David Andrew Griffith, James Alfred Southers, Jr.

Life of this patent

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Abstract

The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; wherein G is R1, R2 and R3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.

Claims16

Dependent claims

A compound selected from the group consisting of

6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-3-carboxamide;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide;
6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[3,2-b]pyridine-3-carboxamide;
6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-2-carboxamide;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-3-carboxamide;
1′-[(2-amino-1H-benzimidazol-5-yl)carbonyl]-1-isopropyl-1,4-dihydrospiro[indazole-5,4′-piperidin]-7(6H)-one;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-methyl-1H-indazole-3-carboxamide;
N-ethyl-5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-(2,2,2-trifluoroethyl)-1H-indazole-3-carboxamide;
6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-2-carboxamide;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrazolo[3,4-b]pyridine-3-carboxamide;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide;
1-isopropyl-1′-{[2-(methylamino)-1H-benzimidazol-5-yl]carbonyl}-1,4-dihydrospiro[indazole-5,4′-piperidin]-7(6H)-one;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-benzimidazole-2-carboxamide;
5-[(1-tert-butyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide;
5-[(1-tert-butyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-3-carboxamide;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-2-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-3-carboxamide;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-2-carboxamide;
1′-[(2-amino-1H-benzimidazol-5-yl)carbonyl]-2-tert-butyl-2,4-dihydrospiro[indazole-5,4′-piperidin]-7(6H)-one;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-ethyl-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-methyl-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-(2,2,2-trifluoroethyl)-1H-indazole-3-carboxamide;
2-tert-butyl-1′-{[2-(methylamino)-1H-benzimidazol-5-yl]carbonyl}-2,4-dihydrospiro[indazole-5,4′-piperidin]-7(6H)-one;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[3,2-b]pyridine-3-carboxamide;
6-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indazole-3-carboxamide;
6-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indole-2-carboxamide;
6-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indole-3-carboxamide;
5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indazole-3-carboxamide;
5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indole-2-carboxamide;
5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indole-3-carboxamide;
5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;
1-[(2-amino-1H-benzimidazol-5-yl)carbonyl]-2′-tert-butyl-2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-7′(6′H)-one;
2′-tea-butyl-1-{[2-(methylamino)-1H-benzimidazol-5-yl]carbonyl}-2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-7′(6′H)-one;
6-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-pyrrolo[3,2-b]pyridine-3-carboxamide;
and
5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-benzimidazole-2-carboxamide;
or a pharmaceutically acceptable salt thereof.

41 more elements

A compound selected from the group consisting of

1′-[(2-aminoquinolin-6-yl)carbonyl]-2-tert-butyl-2,4-dihydrospiro[indazole-5,4′-piperidin]-7(6H)-one;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-methyl-1H-indole-3-carboxamide;
6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-methyl-1H-indole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-cyclopropyl-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-isopropyl-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-propyl-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-(2-methoxyethyl)-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-cyclobutyl-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-oxetan-3-yl-1H-indazole-3-carboxamide;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-Ncyclopropyl-1H-indazole-3-carboxamide;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-methyl-1H-indazole-3-carboxamide;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-ethyl-1H-indazole-3-carboxamide;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-(2-methoxyethyl)-1H-indazole-3-carboxamide;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-isopropyl-1H-indazole-3-carboxamide;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-propyl-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-cyclopropyl-1H-indole-3-carboxamide;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-cyclobutyl-1H-indazole-3-carboxamide;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-oxetan-3-yl-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-(2-methoxyethyl)-1H-indole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-methyl-1H-indole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-ethyl-1H-indole-3-carboxamide;
and
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-cyclopropyl-1H-indole-3-carboxamide;
or a pharmaceutically acceptable salt thereof.

21 more elements

Dependencies are inferred from the claim text.

Facts

Application: 13/452,839Filed 21 Apr 2012 · us provisional application
Priority: 22 Apr 2011
Published: US 2012/0270893 A125 Oct 2012
Granted: 12 Aug 2014
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07D 471/10
In which the condensed system contains two hetero rings: spiro-condensed systems
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 3/00
Drugs for disorders of the metabolism
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents

Family

Application61/478,240Us provisional application · filed 22 Apr 2011
US 2012/0270893 A1Pre-grant publication · published 25 Oct 2012
US 8,802,688 B2This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

A compound selected from the group consisting of

6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-3-carboxamide;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide;
6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[3,2-b]pyridine-3-carboxamide;
6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-2-carboxamide;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-3-carboxamide;
1′-[(2-amino-1H-benzimidazol-5-yl)carbonyl]-1-isopropyl-1,4-dihydrospiro[indazole-5,4′-piperidin]-7(6H)-one;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-methyl-1H-indazole-3-carboxamide;
N-ethyl-5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-(2,2,2-trifluoroethyl)-1H-indazole-3-carboxamide;
6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-2-carboxamide;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrazolo[3,4-b]pyridine-3-carboxamide;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide;
1-isopropyl-1′-{[2-(methylamino)-1H-benzimidazol-5-yl]carbonyl}-1,4-dihydrospiro[indazole-5,4′-piperidin]-7(6H)-one;
5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-benzimidazole-2-carboxamide;
5-[(1-tert-butyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide;
5-[(1-tert-butyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-3-carboxamide;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-2-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-3-carboxamide;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-2-carboxamide;
1′-[(2-amino-1H-benzimidazol-5-yl)carbonyl]-2-tert-butyl-2,4-dihydrospiro[indazole-5,4′-piperidin]-7(6H)-one;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-ethyl-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-methyl-1H-indazole-3-carboxamide;
5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-(2,2,2-trifluoroethyl)-1H-indazole-3-carboxamide;
2-tert-butyl-1′-{[2-(methylamino)-1H-benzimidazol-5-yl]carbonyl}-2,4-dihydrospiro[indazole-5,4′-piperidin]-7(6H)-one;
6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[3,2-b]pyridine-3-carboxamide;
6-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indazole-3-carboxamide;
6-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indole-2-carboxamide;
6-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indole-3-carboxamide;
5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indazole-3-carboxamide;
5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indole-2-carboxamide;
5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indole-3-carboxamide;
5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;
1-[(2-amino-1H-benzimidazol-5-yl)carbonyl]-2′-tert-butyl-2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-7′(6′H)-one;
2′-tea-butyl-1-{[2-(methylamino)-1H-benzimidazol-5-yl]carbonyl}-2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-7′(6′H)-one;
6-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-pyrrolo[3,2-b]pyridine-3-carboxamide;
and
5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-benzimidazole-2-carboxamide;
or a pharmaceutically acceptable salt thereof.

41 more elements

Facts

Application

13/452,839Filed 21 Apr 2012 · us provisional application

Priority

22 Apr 2011

Published

US 2012/0270893 A125 Oct 2012

Granted

12 Aug 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07D 471/10
In which the condensed system contains two hetero rings: spiro-condensed systems
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 3/00
Drugs for disorders of the metabolism
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents