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US 8,802,685 B2Granted
Solid forms of 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses
AssigneeCelgene Corporation
InventorsGeorge Muller, Hon-Wah Man, Benjamin M. Cohen, Ying Li, Jean Xu, William W. Leong
Life of this patent
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Abstract
Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their uses are disclosed.
Claims61
A solid form of 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione:
- or a stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, or clathrate thereof;
- having an X-ray powder diffraction pattern comprising:
- peaks at approximately 14.6° 2θ, 15.6° 2θ, 16.7° 2θ, 21.9° 2θ and 30.0° 2θ as shown in FIG. 1;
- peaks at approximately 10.6° 2θ, 14.7° 2θ, 19.1° 2θ and 25.9° 2θ as shown in FIG. 4;
- peaks at approximately 10.8° 2θ, 15.1° 2θ, 25.1° 2θ and 26.6° 2θ as shown in FIG. 7;
- peaks at approximately 16.7° 2θ, 21.7° 2θ, 21.9° 2θ and 25.8° 2θ as shown in FIG. 10;
- peaks at approximately 7.3° 2θ, 14.6° 2θ, 22.0° 2θ, 30.0° 2θ and 37.0° 2θ as shown in FIG. 13;
- peaks at approximately 14.5° 2θ, 15.7° 2θ, 22.7° 2θ and 29.9° 2θ as shown in FIG. 16;
- or
- peaks at approximately 8.6° 2θ, 13.1° 2θ, 20.5° 2θ and 26.3° 2θ as shown in FIG. 18;
- when analyzed using CuKα X-ray radiation at 1.54 Å.
8 more elements
Dependencies are inferred from the claim text.