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US 8,802,678 B2Granted
Carbonylated (aza) cyclohexanes as dopamine D3 receptor ligands
AssigneeBioprojet
InventorsMarc Capet, Denis Danvy, Nicolas Levoin, Isabelle Berrebi-Bertrand, Thierry Calmels, Philippe Robert, Jeanne-Marie Lecomte, Jean-Charles Schwartz, Xavier Ligneau
Life of this patent
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Abstract
The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent.
Claims14
Compounds of the formula (I):
- wherein NR1R2 is:
- Z is:
- R representing;
- cyanoalkyl;
- monohalogenocyanoalkyl;
- polyhalogenocyanoalkyl;
- hydroxyalkyl;
- monohalogenoalkyl;
- polyhalogenoalkyl;
- monhalogenocycloalkyl;
- polyhalogenocycloalkyl;
- cyanocycloalkyl;
- monohalogenoalkoxy;
- polyhalogenoalkoxy;
- alkoxyalkyl;
- monohalogeno-alkoxyalkyl;
- polyhalogenoalkoxyalkyl;
- alkoxyalkoxyalkyl;
- monohalogeno-alkoxyalkoxyalkyl;
- polyhalogenoalkoxyalkoxyalkyl;
- alkylcarbonyl;
- aryloxy;
- aryloxyalkyl;
- mono- or polyhalogenoaryloxyalkyl;
- arylalkoxy;
- alkenyl;
- cycloalkenyl;
- cycloalkenylalkyl;
- cycloalkenyl fused with benzene;
- alkynyl, dialkylaminoalkyl;
- halodialkylaminoalkyl;
- polyhalogenodialkylaminoalkyl;
- where
- is a non aromatic heterocycle selected from the group consisting of pyrrolidinyl, tetrahydrofuranyl, piperidyl, dihydropyranyl, and 2,3-dihydrofuranyl, optionally substituted with one or more moieties selected from the group consisting of acyl, alkyl and halogen;
- arylaminoalkyl;
- alkoxyalkylamino;
- alkoxy(alkyl)amino;
- cyanoalkylamino;
- alkylcarbonylalkyl;
- acylaminoalkyl;
- aminocarbonylalkyl;
- alkylsulfanylalkyl;
- alkylsulfinylalkyl;
- alkylsulfonylalkyl;
- n being an integer from 1 to 3;
- m being an integer from 0 to 4;
- Ar representing an aryl;
- an heteroaryl selected from the group consisting of pyridyl, pyrimidinyl, quinolinyl and benzothienyl or an aryl fused with a cycloalkyl or an heterocycle selected from the fused systems resulting from the condensation of a phenyl group with a dioxolanyl or a dioxanyl;
- Ar being optionally substituted with one or more alkyl;
- alkenyl;
- alkynyl;
- cyano;
- halogeno;
- alkoxy;
- monohalogenoalkoxy;
- polyhalogenoalkoxy;
- alkoxyalkyl;
- dialkylamino;
- alkylsulfanyl;
- alkylsulfinyl;
- alkylsulfonyl;
- monohalogenoalkylsulfanyl;
- monohalogenoalkylsulfinyl;
- monohalogenoalkylsulfonyl;
- polyhalogenoalkylsulfanyl;
- polyhalogenoalkylsulfinyl;
- polyhalogenoalkylsulfonyl;
- oxazolyl;
- aryl;
- aralkyl;
- aryloxy;
- alkoxy-carbonylamino;
- acyl;
- acylamino;
- aminocarbonyl;
- monoalkylaminocarbonyl;
- dialkylaminocarbonyl;
- alkylsulfonylamino;
- monohalogenoalkyl;
- polyhalogenoalkyl;
- hydroxyl;
- hydroxyalkyl;
- oxoalkyl;
- with the proviso that:
- when Z is NHCH and NR1R2 is
- with Ar representing a phenyl substituted with two chlorine atoms or fused with a carbocycle, then R is not alkenyl;
- or their pharmaceutically acceptable salts, or the polymorphic, crystalline structures of these compounds or their optical isomers, racemates, diastereomers or enantiomers.
84 more elements
Dependencies are inferred from the claim text.