Benzazole derivatives as histamine H4 receptor ligands

A compound of formula (I):

• wherein:
• X represents NR′, S or O;
• HetAr represents a phenyl or heteroaryl, optionally substituted with one or more substituents chosen from halogen, OR″ alkyl, cyano, NR″R′″, —COR″, —COOR″, —CONR″R′″, aryl, -alkylaryl;
• R represents a lower alkyl or H
• R′ represents H, lower alkyl, alkoxyalkyl or alkoxycarbonyl;
• R″, R′″ identical or different independently represent H or alkyl;
• HET representing a non aromatic monocyclic heterocycle containing at least one nitrogen atom, which is linked to R;
• B represents a single bond or an -alkyl- group;
• A represents O, NH or S;
• Ar is a mono or polycyclic aromatic or a mono or polycyclic heteroaromatic which can be optionally substituted with one or more of:
• halo;
• azido;
• cyano;
• hydroxy;
• nitro;
• alkyl;
• alkoxy;
• alkylsulfanyl;
• alkenyl;
• alkynyl;
• alkenyloxy;
• alkenyloxy;
• alkenylsulfanyl;
• alkynylsulfanyl;
• cycloalkoxy;
• cyloalkylalkyl;
• whose alkyl, alkenyl, alkynyl or cycloalkyl part can be substituted with one or more of halo, hydroxy, polyhydroxy, alkoxy, hydroxyalkoxy, cyano, amino, aminoalkyl, alkylamino, dialkylamino, aminoalkylamino, aminoalkylaminocarbonyl, alkoxycarbonylamino, diarylmethylimino (where aryl is optionally substituted with one or more of hydroxy or halo), cycloalkenylimino (where cylalkenyl is optionally substituted with one or more of alkyl, OH), alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, cycloalkyl, polycycloalkyl, cycloalkenyl, polycycloalkenyl, guanidino, alkylcarbonylguanidino, acylguanidino, cyanoguanidino, alkoxycarbonylguanidino, alkoxycarbonyl, alkoxycarbonylalkylamino, alkoxycarbonylalkylcycloalkyl, alkoxycarbonylheterocyclyl, aminocarbonyl, alkylaminocarbonyl, alkylcarbonyl, alkylcarbonylalkoxy, aryloxy, arylsulfanyl, arylsulfinyl, arylsulfonyl, heteroaryl, heterocyclyl (heterocyclyl being optionally substituted with one or more of oxo, amino, imino), heteroaryloxy, heterocyclyloxy, heteroarylamino, heterocyclylamino, hydrazinocarbonyl, hydroxyalkylcycloalkyl, N-alkyl(thioureido), phtalimido, ureido, oxocycloalkenylamino substituted with amino, carbamimidoylheterocyclyl;
• amino;
• alkylamino;
• alkylcarbonyl;
• alkoxycarbonyl;
• alkylsulfanyl;
• alkylsulfinyl;
• alkylsulfonyl;
• alkylsulfonyloxy
• whose alkyl can be substituted with one or more of halo;
• aminocarbonyl which can be N-substituted with one or two of alkyl, aryl, arylalkyl;
• aryl;
• arylalkyl;
• aryloxy;
• arylalkoxy;
• arylalkylamino;
• arylalkylsulfanyl;
• heteroaryl;
• heteroaryloxy
• whose aryl part can be substituted with one or more of amino, halo, alkyl, (poly)haloalkyl, hydroxyalkyl, alkoxy, (poly)haloalkoxy, alkoxycarbonylamino, alkylcarbonyl, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, nitro, cyanoalkyl, or fused with a non aromatic heterocycle;
• heterocyclyl;
• heterocyclyloxy;
• heterocyclylalkoxy
• whose heterocycle can be substituted with one or more of halogenoalkyl, acylamino, acyloxy, amino, alkyl, alkylamino, dialkylamino, aminoalkyl, oxo, carbamimidoyl, halo, hydroxy, hydroxyalkyl, hydroxymethyl, alkoxcarbonyl;
• or
• fused with a non aromatic heterocycle (optionally substituted with one or more of halogens) or carbocycle;
• as well as their enantiomers, diastereomers, mixtures thereof and pharmaceutically acceptable salts, tautomers, hydrates and solvates.