De novo synthesis of glucocorticoids in the epidermis and its uses and applications
AssigneeNew York University
InventorsMarjana Tomic-Canic, Harold Brem, Herbert H. Samuels
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Abstract
The present invention relates to methods and compositions that control, i.e., antagonize/inhibit or agonize/stimulate, de novo glucocorticoid production in the skin. Such methods and compositions can be used for the prevention and/or treatment of a variety of skin conditions, including inflammation, acute wounds, chronic non-healing wounds, keloid, fibrotic or hypertrophic scars, and epithelial-derived cancer.
Claims4
A method of inhibiting de novo glucocorticoid production in the epidermis in a subject in need of such treatment, wherein the subject has a wound of the skin, comprising applying a therapeutically effective amount of a composition comprising an antagonist of the steroid 11-beta-hydroxylase (CYP11B) enzyme to the epidermis of the subject, wherein the antagonist of CYP11B enzyme is metyrapone.
Dependencies are inferred from the claim text.