Purified phospholipid-non-steroidal anti-inflammatory drug associated compositions and methods for preparing and using same

A method of preparing a phospholipid-non-steroidal anti-inflammatory drug composition comprising purified phospholipid-non-steroidal anti-inflammatory drug associated complexes comprising the steps of:

• contacting a selective or nonselective non-steroidal anti-inflammatory drug (sns-NSAID) with an amount of phospholipid (PL) at a temperature between 40° C. and 60° C. in a polar solvent to produce a solution including the PL-sns-NSAID associated complexes, where the amount of the PL is in excess of an amount of the PL normally soluble in the solvent in the absence of the sns-NSAID and where the amount of the excess PL is below an amount based on the amount of sns-NSAID where the PL begins to precipitate out of the solution;
• and
• substantially removing the polar solvent by evaporation to form a phospholipid-non-steroidal anti-inflammatory drug associated composition comprising purified PL-sns-NSAID associated complexes in the form of a homogenous oil;
• wherein a weight ratio of sns-NSAID to PL in the purified phospholipid-non-steroidal anti-inflammatory drug associated composition is between 1:2 and 1:4;
• wherein the sns-NSAID is selected from the group consisting of ibuprofen, aspirin, salicylic acid, naproxen, indomethacin, diclofenac, fluobiprofen flurbiprofen, ketoprofen and mixtures or combinations thereof;
• and
• wherein the polar solvent is acetone.