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US 8,802,654 B2Granted
Antiviral compounds
AssigneeAdenovir Pharma AB
InventorsOlov Sterner, Ulf Ellervik, Karolina Aplander, Anders Carlsson
Life of this patent
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Abstract
Herein are disclosed novel compounds according to Formula (I) and aggregates comprising such compounds. These aggregates are useful to treat and prevent ocular infections caused by a vims, which virus binds to terminal sialic residues present on the cell surface of the cell to be infected by the virus.
Claims20
A compound according to formula (I)
- wherein
- R1 is a methyl or ethyl group;
- R2 is R3, R4 or R8;
- “X” is O, S, or NH;
- and
- “A” is a C3-7 alkanediyl if R2 is R3 and a C2-7 alkanediyl if R2 is R4 or R8, wherein X and R2 are connected to different carbon atoms of said alkanediyl and wherein said different carbon atoms are the carbon atoms in said alkanediyl being most spaced apart;
- R3 is selected from the group consisting of N(C0-3 alkyl)C(O)R5, OC(O)R5, C(O)N(C0-3 alkyl)R5 and C(O)OR5, wherein R5 is a straight carbon chain comprising 14 to 30 carbon atoms;
- said carbon chain is saturated or comprises one or more double and/or triple bond(s);
- furthermore, said carbon chain is unsubstituted or substituted with one or more C1-C5 alkyl groups;
- R4 is a substituent according to formula (II)
- D(CH2)m(OCH2CH2)n(CH2)pER7 (II)
- wherein
- “D” is connected to “A”;
- “D” is selected from the group consisting of N(C0-3 alkyl)C(O), OC(O), C(O)N(C0-3 alkyl), and C(O)O;
- the integer “m” is 0 (zero) to 3;
- the integer “n” is 1 to 15;
- the integer “p” is 0 (zero) to 3;
- “E” is selected from the group consisting of N(C0-3 alkyl)C(O), OC(O), C(O)N(C0-3 alkyl), and C(O)O;
- R7 is selected from the group consisting of R5, as defined above, and R6, wherein R6 is a substituent according to formula (III)
- wherein each R5, independently, is as defined above, and the C2-5 alkanediyl is attached to “E”;
- and
- R8 is selected from the group consisting of N(C0-3 alkyl)C(O)R9, OC(O)R9, C(O)N(C0-3 alkyl)R9 and C(O)OR9, wherein R9 is a substituent according to formula (IV)
- wherein each R5, independently, is as defined above;
- as an acid in its non-charged protonated form, a pharmaceutically acceptable addition salt, solvate, or solvate of a salt thereof.
21 more elements
Dependencies are inferred from the claim text.