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US 8,802,644 B2Granted
Lipid formulation
AssigneeTekmira Pharmaceuticals Corporation
InventorsJianxin Chen, Steven Ansell, Akin Akinc, Joseph Robert Dorkin, Xiaojun Qin, William Cantley, Muthiah Manoharan, Kallanthottathil G. Rajeev, Jayaprakash K. Narayanannair, Muthusamy Jayaraman
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Abstract
The invention features a cationic lipid of formula I, an improved lipid formulation comprising a cationic lipid of formula I and corresponding methods of use. Also disclosed are targeting lipids, and specific lipid formulations comprising such targeting lipids.
Claims35
A lipid formulation comprising:
- (a) a a compound having the formula
- or a salt thereof;
- (b) a neutral lipid;
- (c) a sterol;
- and
- (d) a PEG-modified lipid.
3 more elements
A nucleic acid-lipid particle comprising:
- (a) a lipid particle comprising:
- (i) a compound having the formula
- or a salt thereof,
- (ii) a neutral lipid,
- (iii) a sterol,
- (iv) a PEG-modified lipid;
- and
- (b) a therapeutic siRNA encapsulated in the lipid particle.
5 more elements
Dependencies are inferred from the claim text.