Autophagy-inducing peptide analogs
AssigneesBoard of Regents, The University of Texas System, Baylor College of Medicine
InventorsBeth C. Levine, Sanae Shoji-Kawata, Olivier Lichtarge, Angela D. Wilkins, Nick V. Grishin, Lisa N. Kinch
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Abstract
An autophagy-inducing compound comprises an autophagy-inducing peptide comprising Beclin 1 residues 269-279 immediately N- and C-terminally flanked by moieties R1 and R2, respectively, wherein up to six of said residues may be substituted, R1 and R2 do not naturally flank the Belclin 1 residues, and F270 and F274 are optionally substituted and optionally linked. The compounds may be used to induce autophagy.
Claims20
An autophagy-inducing compound comprising an autophagy-inducing peptide comprising Beclin 1 residues 269-279 (SEQ ID NO:1) or the D-retro-inverso sequence thereof, immediately N- and C-terminally flanked by moieties R1 and R2, respectively, wherein up to six of said residues may be substituted, R1 and R2 do not naturally flank the Beclin 1 residues, and F270 and F274 are optionally substituted and optionally linked.
Dependencies are inferred from the claim text.