Fusion protein composed of matrix metalloproteinase-2 inhibitor peptide derived from amyloid-B precursor protein and tissue inhibitor of metalloproteinase-2
AssigneeOriental Yeast Co., Ltd.
InventorShouichi Higashi
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Abstract
The present invention provides an agent capable of inhibiting MMP-2 specifically. Disclosed is a fusion molecule composed of a β-amyloid precursor protein molecule-derived domain having an activity of selectively inhibiting matrix metalloproteinase-2 and a tissue inhibitor of metalloproteinase capable of binding to latent matrix metalloproteinase. Also disclosed are a pharmaceutical composition, a cancer metastasis and/or angiogenesis inhibitor, a therapeutic and/or prophylactic for cardiovascular diseases, and a matrix metalloproteinase-2 inhibitor, each of which comprises the fusion molecule.
Claims2
A fusion molecule comprising a β-amyloid precursor protein molecule-derived domain and a tissue inhibitor of metalloproteinase capable of binding to latent matrix metalloproteinase-2, said fusion protein comprising the sequence of SEQ ID NO:
- 6 or 7.
Dependencies are inferred from the claim text.