Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
AssigneeStryker Corporation
InventorsDavid C. Rueger, Marjorie M. Tucker, An-Cheng Chang
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Abstract
Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and detects resulting from degenerative diseases such as osteochondritis dessicans.
Claims26
A device for inducing local bone or cartilage formation, comprising:
- an osteogenic protein selected from the group consisting of OP-1, OP-2, OP-3, BMP3, BMP4, BMP5, BMP6, BMP9, BMP10, BMP11, BMP12, BMP15, BMP16, DPP, Vgl, Vgr, 60A protein, GDF1, GDF3, GDF5, GDF6, GDF7, GDF8, GDF9, GDF10, and GDF11;
- a matrix selected from the group consisting of collagen, demineralized bone, apatites, hydroxyapatites, tricalcium phosphates, and admixtures thereof;
- and
- a low viscosity grade of an alkylcellulose;
- wherein when the alkylcellulose is carboxymethylcellulose, said carboxymethylcellulose has a viscosity of 10-200 cP at a concentration of 4% (w/v);
- and
- wherein the ratio of the alkylcellulose to the matrix in said device is 1 part by weight alkylcellulose to 2-10 parts by weight matrix.
Dependencies are inferred from the claim text.