Composition for nasal administration and method for preparing same
AssigneeDaiichi Sankyo Company, Limited
InventorsMasaru Matsumoto, Shuji Takeda, Kyohei Nobori
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Abstract
The invention provides a powdered composition for nasal administration, comprising a physiologically active peptide and cellulose acetate as the base, and having excellent nasal absorption for physiologically active peptides.
Claims8
A powdered composition for nasal administration comprising a physiologically active peptide and cellulose acetate as a base, wherein the composition is obtained by 1) mixing the physiologically active peptide, cellulose acetate and at least 20 wt % of water with respect to the cellulose acetate, and 2) drying the mixture,
- wherein the physiologically active peptide is human glucagon-like peptide-1, human parathyroid hormone (hPTH), hPTH (1-34), human motilin, a human motilin derivative consisting of the amino acid sequence of SEQ ID NO:
- 1, human ghrelin, human atrial natriuretic peptide, brain natriuretic peptide (BNP) or C-type natriurectic peptide (CNP).
A method for preparing a powdered composition for nasal administration, which comprises a physiologically active peptide and cellulose acetate as a base, wherein the method comprises 1) mixing a physiologically active peptide, cellulose acetate and at least 20 wt % of water with respect to the cellulose acetate, and 2) drying the mixture,
- wherein the physiologically active peptide is human glucagon-like peptide-1, human parathyroid hormone (hPTH), hPTH (1-34), human motilin, a human motilin derivative consisting of the amino acid sequence of SEQ ID NO:
- 1, human gherlin, human atrail natriurectic peptide, brain natriurectic, peptide (BNP) or C-type natriuretic peptide (CNP).
Dependencies are inferred from the claim text.