Treatment of inflammatory bowel diseases with mammal beta defensins
AssigneeDefensin Therapeutics ApS
InventorsTanja Maria Rosenkilde Kjaer, Thomas Kruse, Per Holse Mygind, Karoline Sidelmann Brinch, Soeren Kjaerulff, Birgitte Andersen
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Abstract
The present invention relates to treatment of inflammatory bowel diseases with mammal beta defensins.
Claims19
A method of treating an inflammatory bowel disease, the method comprising administering orally to a subject in need of such treatment an effective amount of a human beta defensin comprising an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ ID NO:
- 2, wherein the inflammatory bowel disease is Crohn's disease of the colon.
A method of treating an inflammatory bowel disease, the method comprising administering orally to a subject in need of such treatment an effective amount of a human beta defensin comprising an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ ID NO:
- 2, wherein the subject exhibits normal Paneth cell function.
A method of treating an inflammatory bowel disease, the method comprising administering orally to a subject in need of such treatment an effective amount of a human beta defensin comprising an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ ID NO:
- 2, wherein the subject exhibits normal levels of alpha defensin HD5 and HD6.
Dependencies are inferred from the claim text.