US 8,802,433 B2 · Macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages

Abstract

Disclosed is a highly effective macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages using an active component derived from natural products. A culture obtained by culturing microorganisms belonging to the genus Aureobasidium (Aureobasidium sp.) is used as the active component of the macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages. By means of the macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages, macrophage phagocytosis can be activated, and cytokine production in macrophages can be promoted. In particular, a macrophage phagocytosis-activating composition can activate the phagocytosis of cancer cells or cells damaged or destroyed by anticancer drugs.

Claims1

Dependent claims

A method for activating macrophage phagocytosis by macrophages or macrophage-like cells or promoting cytokine production in macrophages or macrophage-like cells, comprising:

(a) obtaining a culture by culturing a microorganism belonging to Aureobasidium sp.;
and
(b) administering to the macrophages or macrophage-like cells a composition comprising said culture and compound (1)
wherein the microorganism belonging to Aureobasidium sp. is Aureobasidium pullulans M-1 (FERM BP-08615), wherein the composition comprises Compound 1 at 10 μM, wherein the composition is in an amount effective for activating macrophage phagocytosis synergistically by the macrophages or macrophage-like cells or promoting cytokine production synergistically in macrophages or macrophage-like cells.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

13/512,502Filed 3 Dec 2010

Priority

JP 2009-2755533 Dec 2009

Published

US 2012/0329154 A127 Dec 2012

Granted

12 Aug 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

A61K 31/4745
Ortho- or peri-condensed with heterocyclic ring systems: condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
A61K 31/513
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A61K 36/06
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g.…:…
A61P 35/00
Antineoplastic agents

Macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages

Life of this patent

Macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages

Life of this patent

Abstract

Claims1