Micro and nano glass balls embedded in a gel presenting micrometer and nanometer scale curvature and stiffness patterns for use in cell and tissue culturing and a method for making same
OwnerShengyuan Yanginventor
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Abstract
A substrate for use in culturing cells or tissues. The substrate comprises a gel, one or more microstructures partially embedded within a surface of the gel, the one or more microstructures presenting two different curvatures or presenting two different stiffness values or presenting a combination of different curvatures and different stiffness values, wherein the microstructures are disposed at defined locations within the surface of the gel, and wherein the cells and tissues are cultured on an exposed surface of the microstructures.
Claims18
A substrate for use in culturing cells and tissues, the substrate comprising:
- a material sheet;
- a gel disposed above the material sheet;
- microstructure particles partially embedded and immovable within the gel and not attached to the material sheet, a portion of each microstructure particle protruding above a surface of the gel and presenting one or more curved surfaces above the surface of the gel, the curved surfaces comprising indentations and protrusions;
- wherein the surface of the gel comprises an adhesive surface to prevent motion of the microstructures particles relative to the gel;
- the gel and the microstructure particles comprising different materials;
- and
- the substrate for use in culturing cells and tissues on an exposed surface of the microstructure particles.
A substrate for use in culturing cells or tissues, the substrate comprising:
- a material sheet;
- a gel above the material sheet;
- microstructures particles partially embedded and immoveable within the gel and not attached to the material sheet, a portion of a microstructure particle protruding above a surface of the gel and presenting one or more curved surfaces above the surface of the gel, the curved surfaces comprising indentations and protrusions;
- wherein the surface of the gel comprises an adhesive surface to prevent motion of the microstructures particles relative to the exposed gel;
- and
- wherein the microstructures particles are disposed at random locations within the surface of the gel;
- the gel and the microstructure particles comprising different materials;
- and
- the substrate for use in culturing cells and tissues on an exposed surface of the microstructure particles.
Dependencies are inferred from the claim text.