Activated collagen scaffold materials and their special fused active restoration factors
AssigneesYantai Zhenghai Bio-Technology Co., Ltd., Institute of Genetics and Developmental Biology Chinese Academy of Science
InventorsJianwu Dai, Bing Chen, Hang Lin, Wenjie Sun, Wenxue Zhao
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Abstract
Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone damage repair or nerve injury repair. The special fused active restoration factors are fusion proteins comprising a collagen-binding domain (CBD) at N-/C-terminus of cytokines, wherein the collagen-binding domain is a polypeptide consisting of 7-27 amino acid residues with a conservative sequence shown in SEQ ID NO:1 at N-terminus.
Claims15
A fusion protein comprising a collagen binding domain fused to the amino terminus or the carboxyl terminus of a cytokine, wherein the collagen binding domain is a polypeptide consisting of 7-27 amino acid residues, wherein the first 7 amino acid residues from its amino terminal are set forth in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.