Use of Eclipta prostrata and other PPAR-gamma inhibitors in cosmetics and compositions thereof
AssigneeAvon Products, Inc.
InventorsCheng S. Hwang, Uma Santhanam, Manpreet Randhawa
Life of this patent
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Abstract
The present invention describes compositions and methods for improving the appearance of skin, particularly, treating, ameliorating, preventing, delaying, and/or improving one or more signs of excess accumulation and/or production of subcutaneous fat, such as cellulite, and conditions related thereto, by topically applying compositions comprising Eclipta prostrata extracts or other anti-lipid agents.
Claims21
A method for improving the appearance of skin affected by cellulite comprising topically applying thereto an effective amount of an extract of Eclipta prostrata in a cosmetically acceptable vehicle for a time sufficient to improve the appearance of said skin.
A method for improving the appearance of skin affected by cellulite comprising topically applying thereto a composition comprising a peroxisome proliferator-activated receptor-gamma (PPARγ) inhibitor in a cosmetically acceptable vehicle in an amount effective to decrease adipocyte differentiation and/or intracellular triglyceride production and/or accumulation in adipocytes in said area of skin, for a time sufficient to improve the appearance of said skin;
- wherein said PPARγinhibitor is an Eclipta prostrate extract, and
- wherein said PPARγinhibitor further inhibits stearoyl-CoA desaturasel (SCD1) and/or further stimulates tenascin-X production.
A method for reducing the re-occurrence of cellulite in an area previously affected by cellulite comprising topically applying thereto an effective amount an extract of Eclipta prostrata in a cosmetically acceptable vehicle.
A method for reducing obesity comprising topically applying to an area affected by unwanted fat deposition and/or accumulation an effective amount an extract of Eclipta prostrata in a cosmetically acceptable vehicle, for a time sufficient to reduce said unwanted fat.
Dependencies are inferred from the claim text.