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US 8,802,155 B1Granted
Iminosugar in crystalline form
AssigneeDipharma Francis S.R.L.
InventorsEmanuele Attolino, Andrea Malvestiti
Life of this patent
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Abstract
Iminosugar, which possesses known activity as a glycosyltransferase inhibitor, and is used, for example, in the treatment of Gaucher's disease, in crystalline form, a process for its preparation and a pharmaceutical composition thereof.
Claims11
Miglustat, namely N-butyl 1,5-didesoxy-1,5-imino-D-glucitol in crystalline form, herein designated as Form I, having an XRPD spectrum as shown in FIG. 3, in which the most intense peaks (expressed in 2θ°) are to be found at 9.93, 11.82, 14.46, 15.84, 16.41, 17.76, 17.94, 19.41, 20.01, 20.79, 21.21, 22.14, 22.62, 23.40, 24.75, 26.04 and 30.27±0.2° in 2θ;
- and a DSC thermogram as shown in FIG. 4, having an endothermic peak at 129-130° C.
Dependencies are inferred from the claim text.