Microparticles and method for their production
AssigneeAlrise Biosystems GmbH
InventorCelal Albayrak
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Abstract
The invention relates to nano- or microparticles containing an active substance embedded in a polymer matrix and to a method for their production, comprising the steps of: a) effecting precipitation of an active substance in a solution which comprises a polymer dissolved in an organic solvent to obtain a suspension of the active substance, b) mixing the obtained suspension with an aqueous surfactant solution and solidifying the polymer to obtain a suspension of nano- or microparticles which contain an active substance.
Claims7
A method for the preparation of microparticles containing an active substance embedded in a polymer matrix, comprising the steps of:
- a) combining a solution of an active substance dissolved in a smaller amount of a first solvent L1 selected from water or organic solvent with a solution of a polymer in a larger amount of a second organic solvent L2, said solvent L2 dissolving the polymer but being a non-solvent for the active substance, thereby effecting precipitation of the active substance in the combined solvent L1 and solvent L2 solution to obtain a suspension of the active substance having an organic phase as a continuous phase,
- b) mixing the combined solvent L1 and solvent L2 solution with an aqueous surfactant solution wherein L2 is partially soluble in the aqueous surfactant solution and the mixing results in a phase transition from having an organic continuous phase to having an aqueous continuous phase, thereby solidifying the polymer, forming a matrix and embedding the active substance within the polymer to obtain a suspension of microparticles;
- wherein said active substance is selected from the group of compounds that are sensitive to denaturation, degradation in aqueous solutions or shear forces.
Dependencies are inferred from the claim text.