3-dimensional cardiac fibroblast derived extracellular matrix
AssigneeWisconsin Alumni Research Foundation
InventorsEric G. Schmuck, Kurt W. Saupe
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Abstract
A bioscaffold made from an isolated cardiac fibroblast-derived 3-dimensional extracellular matrix (ECM) is disclosed. The bioscaffold can be used as an epicardial patch for the delivery of therapeutic cells into myocardial tissue. Methods of making the 3-dimensional extracellular matrix using cultured cardiac fibroblasts are also disclosed.
Claims11
A bioscaffold for facilitating the delivery of cells to myocardial tissue, the bioscaffold comprising an isolated 3-dimensional cardiac extracellular matrix derived from cardiac fibroblast cells, wherein the isolated 3-dimensional cardiac extracellular matrix:
- (a) comprises the structural proteins fibronectin, collagen type I, collagen type III, and elastin, wherein from 60% to 90% of the structural protein molecules present in the isolated 3-dimensional cardiac extracellular matrix are fibronectin, and
- (b) has a thickness of 20-500 μm.
Dependencies are inferred from the claim text.