Pharmaceutical compositions comprising levetiracetam and process for their preparation

A process of manufacturing a pharmaceutical composition comprising levetiracetam as active ingredient and

• 2.0 to 9.0% per weight of a disintegrant selected from polyvinylpolypyrrolidone and sodium croscarmellose,
• 0 to 3.0% per weight of gliding agent,
• 0.5 to 6.0% per weight of a binder selected from macrogol, microcrystalline cellulose, saccharose, mannitol, and sorbitol, and
• 0.0 to 1.0% per weight of lubricant,
• with respect to the total weight of the pharmaceutical composition,
• which process comprises:
• i) mixing levetiracetam, the gliding agent, the disintegrant and the binder,
• ii) adding the lubricant,
• iii) mixing levetiracetam, the gliding agent, the disintegrant, the binder and the lubricant;
• iv) compacting the mixture obtained in iii),
• v) grinding the mixture obtained in iv), and
• vi) compressing the mixture obtained in v).