Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient

An oral pharmaceutical composition comprising at least three separate and distinct populations of at least one of beads, pellets, tablets and granules provided in a capsule, the at least three separate and distinct populations comprising:

• (i) a first population of a pharmaceutical active comprising a pharmaceutical active substance releasable at a first rate, wherein the first population is selected from the group consisting of:
• a population of beads, a population of pellets, a population of tablets, a population of granules, and any combination thereof;
• (ii) a second population of a pharmaceutical active comprising a pharmaceutical active substance releasable at a second rate, wherein the second population is selected from the group consisting of:
• a population of beads, a population of pellets, a population of tablets, a population of granules, and any combination thereof;
• (iii) a population of a basic substance, wherein the population of the basic substance excludes said pharmaceutical active substance, the population of the basic substance being selected from the group consisting of:
• a population of beads, a population of pellets, a population of tablets, a population of granules, and any combination thereof;
• and
• further comprising (iv) a population of a basic substance, wherein the basic substance is released slower than the basic substance of (ii), wherein the basic substance of (iv) further comprises an enteric coating, wherein a separating layer is provided to separate the basic substance of (iv) from contact with the enteric coating.