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US 8,802,136 B2Granted
Transdermal patch incorporating active agent migration barrier layer
AssigneeMylan Technologies, Inc.
InventorKenneth J. Miller, II
Life of this patent
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AssigneeMylan Technologies, Inc.
InventorKenneth J. Miller, II
Estimating the term…
Devices for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch. One outer layer functions as the primary adhesive layer for adhering the patch to the host. The other inner layer contains at least one active agent to be administered to the host. The inner layer is bonded to the outer layer through an opening provided in an interposed active agent impermeable release layer. The release layer separates a circumferential portion of the active agent containing inner layer from the outer adhesive layer to inhibit migration of the active agent therebetween.
A storage-stable device for the release of an active agent to the skin or mucosa of a host, said device comprising:
A storage-stable device for the release of an active agent to the skin or mucosa of a host, said device comprising:
A storage-stable device for the release of an active agent to the skin or mucosa of a host, the device comprising:
A storage-stable device for the release of an active agent to the skin or mucosa of a host, said device comprising:
Dependencies are inferred from the claim text.
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From the US filing history. Foreign family members aren’t listed.
Characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches: transdermal patches…
Transdermal patches and similar drug-containing composite devices, e.g. cataplasms: characterised by shape or structure; Details concerning…
Apparatus or processes for manufacturing adhesive dressings or bandages: for making transdermal patches
Medicines and medical preparations
Term ended 15 Aug 2023 (estimated)
The present invention relates in general to a device for the release of an active agent to be administered to the skin or mucosa of a host. More particularly, the present invention relates to transdermal patches which inhibit active agent migration by incorporating a releasable barrier layer.
The use of transdermal patches for the delivery of various drug systems has met with increasing success in the pharmaceutical industry, particularly in view of specific problems which have arisen in connection with drugs taken by other means, and because of their implications in terms of long term application of drugs in a particular simple manner. One of the specific problems which has been encountered in connection with the use of various drugs has been the ability to apply a drug in a simple system which employs the drug in admixture with an adhesive base system for application to the skin, or non-adhesive base system having an outer drug permeable adhesive layer. The ability to do this with various types of drugs can be impeded by various considerations, such as differences in viscocity, solubility, therapeutic drug delivery rate, drug migration within the system, and the like.
Simple monolithic transdermal systems incorporate their active agents, i.e., drugs, directly into a single pressure sensitive adhesive layer. These systems have the advantage of being thin, elegant, and relatively easy to manufacture, but must compromise between optimizing the adhesive matrix for drug delivery versus its ability to adhere to the skin.
The subject matter regarded as the invention is particularly pointed out and distinctly claimed in the concluding portion of the specification. The invention, however, both as to organization and method of operation, together with features, objects, and advantages thereof may best be understood by reference to the following detailed description when read with the accompanying drawings in which:
FIG. 1 is a perspective unassembled exploded view of the components of a device for the release of an active agent for application to the skin or mucosa of a host in accordance with one embodiment of the present invention;
FIG. 2 is an assembled cross-sectional view of the device shown in FIG. 1;
In describing the preferred embodiments of the invention illustrated in the drawings, specific terminology will be used for the sake of clarity. However, the invention is not intended to be limited to the specific terms so selected, and it is to be understood that each specific term includes all technical equivalents that operate in a similar manner to accomplish a similar purpose.
Referring now to the drawings, wherein like elements represent like elements, there is shown in FIG. 1 the unassembled components of a device for the administration of one or more active agents to the skin or mucosa of a host in accordance with one embodiment of the present invention. The device 100 generally includes an outer patch 102, an outer patch release layer 104, an inner patch 106 and an inner patch release layer 108. The outer and inner patches 102, 106 and release layers 104, 108, which are typically planar layers, are assembled to one another to form a laminate composite structure in the nature of a double disk device as to be described hereinafter.
The outer patch 102 includes a flexible adhesive layer 110 and a co-extensive protective backing layer 112 adhered thereto. The adhesive layer 110 provides the primary adhesion of the device 100 to the skin or mucosa of a host. Preferably, the adhesive layer 110 is a pressure-sensitive adhesive suitable for contact with the skin or mucosa of a host, e.g., dermatologically acceptable. Optionally, the adhesive layer may be admixed with an active agent or other drug to be administered to a host. In which case, the adhesive layer 110 will be formed from active agent permeable material to allow administration of the active agent.