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US 8,802,133 B2Granted
Silicone scar treatment preparation
AssigneeAdvanced Bio-Technologies, Inc.
InventorPaul Guilbaud
Life of this patent
Estimating the term…
Abstract
Disclosed is 1) a method for greatly increasing the solubility of useful actives in siloxane matrix-forming preparations, and 2) the associated preparations, themselves. Volatilizing coagents are utilized to give novel gels containing heretofore siloxane-insoluble additives.
Claims13
A spreadable preparation for aiding in wound healing and improving the characteristics of the post-epithelialially developed tissue at a wound site, the preparation comprising:
- a) a volatile component;
- b) siloxane matrix precursors capable of forming a siloxane matrix at temperatures in the range of from about 95 to 100 degrees Fahrenheit during evaporation of the volatile component and comprising an amount ranging from 25 wt % to 60 wt % of the overall spreadable preparation;
- c) an active component having low miscibility and low solubility in the siloxane matrix precursors;
- and
- d) a volatile coagent, the volatile coagent including at least one selected from the group consisting of dimethyl isosorbide, isopropyl myristate, pentylene glycol, and isopropyl myristate;
- wherein:
- the volatile coagent being capable of forming a complex with the active component to form a solubilized active component;
- the complex being miscible in said siloxane matrix precursors;
- the active component being mobile within a siloxane matrix such that the active component can move to the wound site;
- the active component being a steroid compound in an amount ranging from 0.5 wt % to 3.0 wt % of the overall composition or an agent having sun screening activity, the agent having sun screening activity comprising octinoxate (ISP escalol 557) and octisalate (ISP escalol 587);
- and
- at least a portion of the volatile coagent evaporates from the preparation upon the formation of the siloxane matrix.
9 more elements
A composition for topical application to a human subject in need thereof, the composition comprising:
- a) a volatile component having a cyclic siloxane and being present in the composition at a concentration ranging from 12 wt % to 45 wt % of the overall composition;
- b) siloxane matrix precursors having dimethicone and dimethicone cross polymers and ranging from 25 wt % to 60 wt % of the overall composition;
- c) an active component comprising a steroid compound in an amount ranging from 0.5 wt % to 3.0 wt % of the overall composition;
- and
- d) a glycol containing compound being present in the composition at a concentration ranging from 5 wt % to 50 wt % of the overall composition.
2 more elements
Dependencies are inferred from the claim text.