Risperidone-containing PLA:PGA implants and methods of use thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsSteven Siegel, Karen Winey
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Abstract
The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.
Claims20
An implantable composition comprising a therapeutic drug and a polymer, said polymer comprising polylactic acid (PLA) and optionally polyglycolic acid (PGA) in a PLA:PGA molar ratio between 50:50 and 100:0, wherein said therapeutic drug is present in an amount of 10%-60% of the mass of said composition, and said polymer is present in an amount of 40%-90% of the mass of said composition, wherein said composition is capable of exhibiting the time to maximum serum concentration ranging from about 20 days to about 190 days after implanting said composition in a subject, and wherein said therapeutic drug is risperidone or 9-OH-risperidone.
An implantable composition comprising:
- poly (lactide/glycolide) (PLGA) copolymer at a concentration of about 40-90% (w/w) and an antipsychotic agent at a concentration of about 10-60% (w/w), wherein the lactide:glycolide molar ratio of said poly (lactide/glycolide) copolymer is from about 90:10 to about 50:50, wherein said composition is capable of exhibiting the time to maximum concentration of said antipsychotic agent in a subject from about 20 days to about 190 days, and wherein said antipsychotic agent is risperidone or 9-OH-risperidone.
A method for obtaining a time to maximum concentration of risperidone from about 20 days to about 190 days, in a subject, the method comprising:
- implanting an implant composition that comprises said risperidone and a polymer, said polymer comprising polylactic acid (PLA) and optionally polyglycolic acid (PGA) in a PLA:PGA molar ratio between 50:50 and 100:0, wherein said risperidone is present in an amount of 10%-60% of the mass of said composition, and said polymer is present in an amount of 40%-90% of the mass of said composition, thereby obtaining said time to maximum concentration of risperidone from about 20 days to about 190 days in said subject.
A method for obtaining a time to maximum concentration of risperidone from about 20 days to about 190 days, in a subject, the method comprising:
- implanting an implant composition that comprises poly (lactide/glycolide) (PLGA) copolymer at a concentration of about 40-90% (w/w) and said risperidone at a concentration of about 10-60% (w/w), wherein the lactide:glycolide molar ratio of said poly (lactide/glycolide) copolymer is from about 90:10 to about 50:50, thereby obtaining said time to maximum concentration of risperidone from about 20 days to about 190 days in said subject.
Dependencies are inferred from the claim text.