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US 8,802,126 B2Granted
Polyester implantable medical device with controlled in vivo biodegradability
AssigneeAbbott Cardiovascular Systems Inc.
InventorYunbing Wang
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Abstract
This invention relates to blends of high, optionally medium, and low molecular weight polyesters where at least the low molecular weight polyester is substituted with an acidic moiety, the biodegradation of the blends being controllable by selection of the mean molecular weigh of each fraction, the quantity of each fraction in the blend and the amount and pKa of the acidic moiety(ies).
Claims27
A stent, comprising:
- a blend of a high molecular weight polyester and a low molecular weight polyester, wherein
- the high molecular weight polyester has a molecular weight of about 200,000 Da to about 1,000,000 Da;
- the low molecular weight polyester has a molecular weight of about 200 Da to about 20,000 Da;
- the low molecular weight polyester comprises about 0.1% w/w to about 5% w/w of the blend;
- and,
- at least a portion of the low molecular weight polyester is substituted with an acidic moiety.
3 more elements
Dependencies are inferred from the claim text.