Endosseous implant
AssigneesUniversite De Geneve, Ecole Polytechnique Federale de Lausanne
InventorsPierre Descouts, Björn-Owe Aronsson, Michael Grätzel, Carine Viornery, Peter Péchy
Life of this patent
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Abstract
Endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture, which is characterized in that said surface has been treated with at least one selected organic phosphonate compound or a pharmaceutically acceptable salt or ester or an amide thereof; process for producing said implants.
Claims16
A compound corresponding to the formula (I):
- A-[P(O)(OH)2]p (I),
- or a pharmaceutically acceptable amide or salt thereof, wherein
- A is a residue of a cyclic, saturated or unsaturated, hydrocarbon with n carbon atoms, carrying p phosphonic acid groups,
- wherein said residue is substituted by hydroxyl and/or carboxyl or said residue is unsubstituted, and
- wherein said residue is interrupted by one or more oxygen and/or sulphur atoms or said residue is not interrupted, and
- wherein n is a number from 2 to 10, and p is 2, provided each phosphonic acid group is bound to a different carbon atom within the same molecule.
A compound corresponding to the formula (I):
- A-[P(O)(OH)2]p (I),
- or a pharmaceutically acceptable ester, amide or salt thereof, wherein
- A is a residue of a linear, branched or cyclic, saturated or unsaturated, hydrocarbon with n carbon atoms, carrying p phosphonic acid groups,
- wherein said residue is interrupted by one or more sulphur atoms, and
- wherein said residue is substituted by hydroxyl and/or carboxyl or said residue is unsubstituted, and
- wherein n is a number from 2 to 10, and p is 2, provided each phosphonic acid group or phosphonic acid ester group is bound to a different carbon atom within the same molecule.
A compound corresponding to the formula (I):
- A-[P(O)(OH)2]p (I),
- or a pharmaceutically acceptable amide or salt thereof, wherein
- A is a residue of a branched or cyclic, unsaturated hydrocarbon with n carbon atoms, carrying p phosphonic acid groups,
- wherein said residue is substituted by hydroxyl and/or carboxyl or said residue is unsubstituted, and
- wherein said residue is interrupted by one or more oxygen and/or sulphur atoms or said residue is not interrupted, and
- wherein n is a number from 2 to 10, and p is 2, provided each phosphonic acid group is bound to a different carbon atom within the same molecule.
A compound corresponding to the formula (I):
- A-[P(O)(OH)2]p (I),
- or a pharmaceutically acceptable ester, amide or salt thereof, wherein
- A is a residue of a linear, branched or cyclic, unsaturated hydrocarbon with n carbon atoms, carrying p phosphonic acid groups,
- wherein said residue is interrupted by one or more oxygen and/or sulphur and/or nitrogen atoms, and
- wherein said residue is substituted by hydroxyl and/or carboxyl or said residue is unsubstituted, and
- wherein n is a number from 2 to 10, and p is 2, provided each phosphonic acid group or phosphonic acid ester group is bound to a different carbon atom within the same molecule.
Dependencies are inferred from the claim text.