Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue of bone
AssigneeThe Trustees of Columbia University in the City of New York
InventorsHelen H. Lu, Jeffrey Spalazzi, Kathie Dionisio
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Abstract
Methods and apparatuses are provided for musculoskeletal tissue engineering. For example, a scaffold apparatus is provided which comprises microspheres of selected sizes and/or composition. The microspheres are layered to have a gradient of microsphere sizes and/or compositions. The scaffold provides a functional interface between multiple tissue types.
Claims13
A scaffold apparatus for musculoskeletal tissue engineering, said apparatus comprising three or more phases, a first end designed to promote growth and maintenance of bone tissue and a second end opposite the first end designed to promote growth and maintenance of a tissue which is other than bone tissue, wherein at least one of the three or more phases comprises a porous fiber mesh formed from degradable electrospun polymer fiber.
A scaffold apparatus for soft tissue-to-bone interface tissue engineering comprising:
- a first region comprising composite microspheres of a first size and composition optimized to promote growth, proliferation, and differentiation of a first cell type for integration and growth of bone;
- a second region joined to the first region, said second region comprising microspheres and/or a fibrous mesh, said microspheres and/or fibrous mesh having a second size and a second composition;
- a third region joined to the second region, said third region comprising microspheres and/or a fibrous mesh, said microspheres and/or fibrous mesh having a third size and a third composition, and said second and third regions being optimized to promote growth, proliferation and differentiation of a second cell type for integration and formation of a first soft tissue and/or bone;
- and
- a fourth region joined to the third region, said fourth region comprising microspheres and/or a fibrous mesh, said microspheres and/or fibrous mesh having a composition adapted to promote growth, proliferation, and differentiation of a third cell type for integration and growth of a second soft tissue and/or bone.
Dependencies are inferred from the claim text.