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US 8,802,109 B2Granted
Herpes simplex virus mutant ICP0
AssigneesUniversity of Kansas, Southern Illinois University
InventorsDavid Davido, William Halford
Life of this patent
Estimating the term…
Abstract
A mutant herpesvirus that has a mutated gene that encodes a mutant infected cell protein 0 (ICP0) can be used in therapeutic methods as well as in diagnostics and research experiments. The encoded mutant ICP0 protein can be altered in one or more regions of ICP0 that are substantially conserved between two or more herpesviruses and/or within a phosphorylation region. The mutant herpesvirus can be substantially avirulent and immunogenic.
Claims14
A mutant herpesvirus comprising:
- a mutated gene that encodes:
- a mutant infected cell protein 0 (ICP0) that includes at least one in-frame deletion in a nuclear localization signal (NLS) region of ICP0.
An immunogenic composition comprising:
- a pharmaceutically acceptable carrier;
- and
- a mutant herpes simplex virus comprising a gene that encodes:
- a mutant infected cell protein 0 (ICP0) that includes at least one in-frame deletion in a nuclear localization signal (NLS) region of ICPO.
1 more element
A mutant herpes simplex virus 2 (HSV-2) comprising:
- a mutated gene that encodes:
- a mutant infected cell protein 0 (ICP0) that includes at least one in-frame deletion in one or more of a RING finger region or a nuclear localization signal (NLS) region of ICP0.
Dependencies are inferred from the claim text.