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US 8,802,104 B2Granted
Parathyroid hormone receptor activation and stem and progenitor cell expansion
AssigneeThe General Hospital Corporation
InventorsDavid T. Scadden, Laura M. Calvi, Gregor Adams, Henry M. Kronenberg
Life of this patent
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Abstract
The invention relates to methods for manipulating hematopoietic stem or progenitor cells, mesenchymal stem cells, epithelial stem cells, neural stem cells and related products through activation of the PTH/PTHrP receptor in neighboring cells.
Claims9
A method for preparing a population of cells for enhancing the growth or maintenance of stem cells selected from the group consisting of mesenchymal stem cells, epithelial stem cells and neural stem cells, the method comprising:
- contacting a cell expressing a PTH/PTHrP receptor with an agent that activates the PTH/PTHrP receptor in an amount effective to support the growth or maintenance of mesenchymal stem cells, epithelial stem cells or neural stem cells.
Dependencies are inferred from the claim text.