HER2/neu-specific antibodies and methods of using same
AssigneeMacroGenics, Inc.
InventorsLeslie S. Johnson, Ling Huang, Nadine Tuaillon, Ezio Bonvini
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Abstract
This invention relates to antibodies that specifically bind HER2/neu, and particularly chimeric 4D5 antibodies to HER2/neu, which have reduced glycosylation as compared to known 4D5 antibodies. The invention also relates to methods of using the 4D5 antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.
Claims15
An isolated polypeptide comprising a chimeric 4D5 immunoglobulin light chain variable domain comprising the amino acid sequence of SEQ ID NO:
- 4.
An isolated polypeptide comprising an immunoglobulin heavy chain comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 9, SEQ ID NO:
- 11, and SEQ ID NO:
- 13.
Dependencies are inferred from the claim text.