Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
AssigneePrecision Biologics, Inc.
InventorsJ. Andrew Bristol, Judith A Kantor
Life of this patent
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Abstract
The present invention provides for recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens, along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to the nucleic acids, and uses for these antibodies, nucleic acids and amino acids.
Claims10
A method for treating colorectal or pancreatic carcinoma-associated pathologies comprising administering to a subject an effective amount of an antibody selected from the group consisting of a monoclonal, Fab, Fab′, F(ab′)2, and Fv, that binds 16C3 colorectal and pancreatic carcinoma-associated antigens (16C3 CPAA), wherein said antibody comprises
- a. a light chain, said light chain comprises (i) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 4;
- (ii) a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 2 or SEQ ID NO:
- 5;
- and (iii) a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 3 or SEQ ID NO:
- 6, and
- b. a heavy chain, said heavy chain comprises (i) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 7;
- (ii) a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 8 or SEQ ID NO:
- 10;
- and (iii) a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 9 or SEQ ID NO:
- 11.
A method for promoting tumor regression in a subject comprising administering to said subject an effective amount of an antibody selected from the group consisting of a recombinant monoclonal, Fab, Fab′, F(ab′)2, and Fv, that binds 16C3 colorectal and pancreatic carcinoma-associated antigens (16C3 CPAA), wherein said antibody comprises
- a. a light chain, said light chain comprises (i) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 4;
- (ii) a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 2 or SEQ ID NO:
- 5;
- and (iii) a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 3 or SEQ ID NO:
- 6, and
- b. a heavy chain, said heavy chain comprises (i) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 7;
- (ii) a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 8 or SEQ ID NO:
- 10;
- and (iii) a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 9 or SEQ ID NO:
- 11.
Dependencies are inferred from the claim text.