Compositions and methods for modulating an immune response
AssigneeDuke University
InventorsSoman Abraham, Kam Leong, Herman Staats, Ashley St. John
Life of this patent
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Abstract
Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2, IL-23, IL-1α, IL-10, IL-18, and combinations thereof. Further provided are methods of making a nanoparticle comprising mixing a first composition comprising heparin with a second composition comprising chitosan in the presence of at least one cytokine to form a third composition. Further provided are methods of modulating an immune response comprising co-administering to a subject an antigen or vaccine with nanoparticles comprising heparin, chitosan, and at least one cytokine.
Claims5
A method of enhancing an immune response in a subject comprising administering to the subject a nanoparticle comprising:
- heparin;
- and
- chitosan,
- wherein the heparin and the chitosan nanoparticle encapsulates at least one immunomodulatory agent, in an amount effective to increase an amount of IgA, IgG1, IgG2, or a combination thereof, wherein the at least one immunomodulatory agent is selected from the group consisting of TNF, IL-12, IL-1α, IL-2, IL-23, IL-18, IL-10, and IFN,
- wherein the nanoparticle has an absorbance at 400 nm of at least 0.015 at a pH of 6 to 8.5, and
- wherein the nanoparticle is administered via injection.
Dependencies are inferred from the claim text.