Bi-functional co-polymer use for opthalmic and other topical and local applications
AssigneeEyeon Particle Sciences LLC
InventorsEugene R. Cooper, David M. Kleinman, Andrew Loxley, Mark Mitchnick
Life of this patent
Estimating the term…
Abstract
The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
Claims37
A method for prolonging the stability of ocular surface tear film of a subject, comprising contacting an ocular surface of said subject with a composition comprising a graft copolymer having a positively charged backbone and hydrophilic water soluble non-ionic side chains wherein the graft copolymer is PLL-g-PEG in an amount and for a duration so as to prolong the stability of said tear film in said subject wherein the composition further comprises a PLURONIC block copolymer, and a demulcent.
A method for prolonging the stability of ocular surface tear film of a subject, comprising contacting an ocular surface of said subject with a composition comprising PLL-g-PEG in an amount and for a duration so as to prolong the stability of said tear film in said subject, wherein said PLL-g-PEG is present in said composition at a concentration of 0.1 to 3 wt %, and wherein the stability of the tear film in said subject is maintained for up to two hours.
Dependencies are inferred from the claim text.