Use of the spin crossover complex [mx+(LY)HW]AN)Z as a magnetic resonance imaging contrast agent
AssigneeKarlsruher Institut Fuer Technologie
InventorsChandrasekar Rajadurai, Mario Ruben, Danuta Kruk
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Abstract
A method for magnetic resonance imaging of a human or animal body includes providing a spin crossover complex having the general formula [Mx+(Ly)Hw]AN)z wherein, MX+ is a positively charged metal ion, Ly is a heteroaromatic ligand containing at least one nitrogen atom in its ring system, AN is a negatively charged inorganic anion, w is 0, 1 or 2, x is 2 or 3, y is 2 or 3, and z is 2, 3 or 4. The spin crossover complex is applied as a contrast agent in a magnetic resonance imaging of the human or animal body.
Claims19
A method for magnetic resonance imaging of a human or animal body, the method comprising:
- introducing into the human or animal body a contrast agent comprising a spin crossover complex of formula
- [M(Ly)Hw](AN)z
- wherein,
- M is Fe2+,Fe3+, or Co2+,
- L is 4′-(4′″-pyridyl)-1,2′:6′1″-bispyrazolylpyridine,
- AN is a negatively charged inorganic anion,
- w is 0, 1, or 2,
- y is 2 or 3, and
- z is 2, 3, or 4;
- and
- conducting magnetic resonance imaging on the human or animal body.
Dependencies are inferred from the claim text.