Chromatography methods
AssigneeIronstone Separations, Inc.
InventorsJames D. McChesney, Douglas L. Rodenburg
Life of this patent
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Abstract
This application discloses, in part, 1) a stationary phase column and compression designs for preparative chromatography, 2) a method of improving performance of silica gel chromatography by controlling the hydration of silica gel and acidifying the mobile phase, and 3) a method of extending the life of a silica gel column packing by cleaning or regenerating the silica gel stationary phase.
Claims6
A preparative chromatography column comprising a column tube having a proximal end and a distal end, a proximal distribution assembly comprising an inlet feature on an inlet piston in the proximal end of the column tube, a distal distribution assembly comprising an outlet feature on an outlet piston in the distal end of the column tube, a bed volume between the inlet piston and the outlet piston, wherein the inlet piston is coupled with a thrust washer, a disc spring washer, a disc spring washer guide and a compression cylinder, and wherein the inlet piston is biased against the disc spring for compressing the disc spring washer when the bed volume is filled with a stationary phase.
Dependencies are inferred from the claim text.