Intravesical drug delivery device

A drug delivery device for deployment into the urinary bladder of a human patient, the device comprising:

• a water-permeable, silicone tubular body having an internal reservoir, the internal reservoir being in the form of an elongated central lumen with closed ends;
• and
• a solid drug formulation housed within the internal reservoir of the body, the solid drug formulation comprising lidocaine hydrochloride,
• wherein the drug delivery device is deformable from a first configuration suited for passing the drug delivery device through a lumen of a urethral catheter or cystoscope into the bladder to a second configuration suited for retaining the device in the bladder upon exiting the urethral catheter or cystoscope, the drug delivery device being configured to assume the second configuration upon exiting the urethral catheter or cystoscope without an additional procedure to load a pharmaceutical solution into the device after the device is released into the bladder,
• wherein the tubular body has at least one aperture therethrough and is configured to control release of the lidocaine hydrochloride through the aperture.

A drug delivery device for deployment into the urinary bladder of a patient, the drug delivery device comprising:

• a body having an annular, tube-shaped, water permeable wall bounding a central lumen, the wall comprising silicone;
• and
• a solid drug formulation comprising a drug, the solid drug formulation being loaded in the central lumen,
• wherein the drug delivery device is deformable from a first configuration suited for passing the drug delivery device through a lumen of a urethral catheter or cystoscope into the bladder to a second configuration suited for retaining the device in the bladder upon exiting the urethral catheter or cystoscope,
• wherein the wall is configured to permit diffusion of water through the wall into the central lumen to solubilize the drug formulation and the body comprises at least one aperture configured to control release of the solubilized drug through the aperture at least in part by osmotic pressure.

A drug delivery device for deployment into the urinary bladder of a patient, the drug delivery device comprising:

• a body having an annular, tube-shaped, water permeable wall bounding a central lumen, the lumen being elongated along a longitudinal axis and having a cross-section perpendicular to the longitudinal axis;
• and
• a solid drug formulation comprising a drug, the solid drug formulation disposed in the lumen and filling the cross-section of the central lumen,
• wherein the drug delivery device is deformable from an initial, uncompressed shape that is effective to prevent voiding of the device from the bladder to an elongated shape that is effective to permit deploying the device from a deployment instrument positioned in a urethra of the patient,
• wherein the drug delivery device is configured, upon exiting the deployment instrument, to return from the elongated shape to the initial shape, and
• wherein the wall is configured to permit diffusion of water through the wall into the central lumen to solubilize the drug formulation and the body comprises at least one aperture suited to dispense the solubilized drug driven at least in part by osmotic pressure in the central lumen.