Robotic catheter system and methods

A robotic medical system, comprising:

• an elongate flexible sheath instrument comprising a sheath instrument base and a sheath instrument lumen;
• an elongate flexible guide instrument positioned in the sheath instrument lumen, the guide instrument comprising a guide instrument base and a guide instrument lumen;
• an instrument driver having a sheath instrument interface and a guide instrument interface,
• wherein the sheath instrument base may be operatively and removably coupled to the sheath instrument interface, such that movement of the sheath instrument may be robotically controlled by the instrument driver via the sheath instrument interface,
• wherein the guide instrument base may be operatively and removably coupled to the guide instrument interface, such that movement of the guide instrument may be robotically controlled by the instrument driver via the guide instrument interface, and
• wherein the sheath instrument interface and guide instrument interface are independently translatable relative to one another, such that the sheath instrument and guide instrument are axially translatable relative to the sheath instrument;
• and
• an elongate guidewire positioned in the guide instrument lumen, the guidewire having a proximal end coupled to an actuator, the actuator being removably coupled to the instrument driver, wherein movement of the guidewire may be robotically controlled by the actuator.