Methods to reduce variance in OCT analysis of the macula

A method of analyzing the degree of abnormality in a patient's eye comprising:

• collecting a set of measurements of the patient's eye over a region;
• determining a representative value of the measurements in each of a set of sub-regions;
• identifying, the minimum representative value determined;
• comparing the minimum value to a distribution of minimum values from a collection of measurements from a plurality of subjects;
• and
• storing or displaying information quantifying the comparison and
• further comprising modifying the set of measurements to account for anatomical variation prior to the determination of a representative value and wherein the modification is based on a model of the eye.

A method of analyzing the degree of abnormality in a patient's eye comprising:

• collecting a set of measurements of the patient's eye over a region;
• determining a representative value of the measurements in each of a set of sub-regions;
• identifying, the minimum representative value determined;
• comparing the minimum value to a distribution of minimum values from a collection of measurements from a plurality of subjects wherein the plurality of subjects have normal, healthy eyes;
• and
• storing or displaying information quantifying the comparison;
• further comprising reducing the variance in the collection of measurements from the plurality of normal subjects prior to comparison wherein the variance is reduced by spatially transforming the collection of measurements and wherein the spatial transformation is a radial transformation based on a structural feature associated with the fovea and wherein the structural feature is a measure of the foveal size.