Determination of cardiac resynchronization therapy settings

A system for determining cardiac resynchronization therapy settings, said system comprising:

• an electrode connector connectable to a first electrode configured to be arranged in connection with a first chamber of a heart of a subject and N≧2 electrodes configured to be arranged in connection with a second chamber of the heart;
• a pulse generator connected to the electrode connector and configured to generate pacing pulses to be applied to the first electrode and the N electrodes;
• a pulse generator controller connected to the pulse generator and configured to control the pulse generator to generate the pacing pulses to be applied to the first electrode and the N electrodes of a defined scheme of interchamber delays defining, for each electrode of the N electrodes, a maximum interchamber delay, a minimum interchamber delay and an intermediate interchamber delay with regard to the timing of applying a pacing pulse to the first electrode;
• a width processor configured to determine, for each combination of N interchamber delays of the defined scheme, a width parameter value representative of a width of a resulting R wave, if the first and second chambers are first and second ventricles, or of a resulting P wave, if the first and second chambers are first and second atria, occurring in an electrocardiogram representing signal recorded for the heart;
• a model processor configured to estimate, based on the width parameter values, an nth order parametric model defining the width parameter as a function of a respective interchamber delay for each electrode of the N electrodes, n≧2;
• a delay processor configured to determine, based on the nth order parametric model and for each electrode of the N electrodes, a candidate interchamber delay that minimizes the width parameter;
• and
• a memory configured to store cardiac resynchronization settings obtained based on the N candidate interchamber delays.