US 8,796,485 B2 · CaSR agonists

Abstract

By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.

Claims5

Dependent claims

A glutamic acid derivative of formula (I) or a pharmaceutically acceptable thereof:

wherein R1 and R3-R5 are each independently selected from the group consisting of a hydrogen atom, a halogeno group, a hydroxyl group, a nitro group, —NH2, an optionally substituted alkyl group having 1 to 6 carbon atoms, and an optionally substituted alkoxy group having 1 to 6 carbon atoms;
R2 is selected from the group consisting of a nitro group, a sulfonic acid group,
R6 is a hydroxyl group;
R7 is a hydrogen atom or an optionally substituted alkyl group having 1 to 6 carbon atoms;
and
X is a methylene group or an oxygen atom.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/079,273Filed 4 Apr 2011 · continuation

Priority

JP 2008-2580033 Oct 2008

Published

US 2011/0251418 A113 Oct 2011

Granted

5 Aug 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

C07C 237/04
Having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton: the carbon skeleton being acyclic and…
A23L 27/204
Synthetic spices, flavouring agents or condiments: aromatic compounds
A23L 27/22
Containing amino acids: containing glutamic acids
A23L 33/175
Amino acids, peptides or proteins: amino acids

CaSR agonists

Life of this patent

CaSR agonists

Life of this patent

Abstract

Claims5