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US 8,796,474 B1Granted
Macrolide compounds and methods and intermediates useful for their preparation
AssigneeRutgers, The State University of New Jersey
InventorsLawrence J. Williams, Hiyun Kim, Kai Liu, Rojita Sharma
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Abstract
The present invention provides intermediate compounds and synthetic methods that can be used to prepare complex cyclic compounds including macrolides. The invention also provides cyclic compounds that have useful biological properties such as antiinfective, antiinflammatory, or antitumor properties.
Claims4
A compound of formula 239a:
- wherein:
- R239a is H or a hydroxy protecting group;
- R239b is H or a hydroxy protecting group;
- and
- Rx is H, halo, amino, or cyano.
2 more elements
A compound of formula 239a:
- wherein:
- R239b is H or benzyl;
- R239b is H or benzyl;
- and
- Rx is fluoro, chloro, or bromo.
2 more elements
A compound of formula 239:
A compound of formula 239a:
- wherein:
- R239a is H or a hydroxy protecting group;
- R239b is H or a hydroxy protecting group;
- and
- Rx is H.
2 more elements
Dependencies are inferred from the claim text.