Substituted octahydrocyclopenta[c]pyrroles as calcium channel modulators

A compound of formula (I),

• or a pharmaceutically acceptable salt thereof, wherein
• α is a single bond;
• R1 is —N(Rx)C(O)G3;
• Ra and Rb, at each occurrence, are each independently hydrogen, alkyl, arylalkyl, halogen, haloalkyl, hydroxy, hydroxyalkyl, or OR1a;
• wherein the aryl of arylalkyl is unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of alkyl, haloalkyl, and halogen;
• R1a is alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, or haloalkyl;
• wherein said aryl, the aryl of arylalkyl, cycloalkyl and the cycloalkyl of cycloalkylalkyl are independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of alkyl, haloalkyl, and halogen;
• Rx is hydrogen or alkyl;
• R2a is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, or haloalkyl;
• wherein said aryl, the aryl of arylalkyl, cycloalkyl, and the cycloalkyl of cycloalkylalkyl are independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of alkyl, haloalkyl, and halogen;
• R2b is alkyl or haloalkyl;
• G3, at each occurrence, is independently aryl or heteroaryl;
• wherein G3 at each occurrence is independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, haloalkyl, halogen, nitro, N(R2a)2, N(R2a)C(O)R2a, OR2a, C(O)R2a, C(O)OR2a, C(O)N(R2a)2, SO2R2b, and SO2N(R2a)2;
• m, at each occurrence, is independently 1, 2, 3, 4, 5, or 6;
• R2 is alkyl, haloalkyl, G3 or —(CRaRb)m-G3;
• R3 is hydrogen, alkyl, haloalkyl, G3 or —(CRaRb)m-G3;
• R4 is hydrogen, G5, or —(CRaRb)m-G3;
• and
• G5 is aryl or heteroaryl;
• wherein G5 is independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, haloalkyl, halogen, nitro, N(R2a)2, N(R2a)C(O)R2a, OR2a, C(O)R2a, C(O)OR2a, C(O)N(R2a)2, SO2R2b, and SO2N(R2a)2;
• and wherein the G5 is other than quinolizinone or quinolone.