Cyclohexylamine isoquinolone derivatives

A method of treating pulmonary hypertension, glaucoma, neuronal degeneration or Alzheimer's disease in a patient comprising administering to said patient an effective amount of at least one compound of the formulae (I) or (I′):

• wherein
• R1 is H;
• R2 is H;
• R3 is H;
• R4 is H, halogen, OH, CN, (C1-C6)alkyl;
• R5 is H, halogen, CN, NO2, (C1-C6)alkyl, (C2-C6)alkenyl, —NH2, NH—SO2H, NH—SO2—(C1-C6)alkyl, NH—C(O)—(C1-C6)alkyl, C(O)N[(C1-C6)alkyl]2, C(O)OH or C(O)O—(C1-C6)alkyl;
• R6 and R6′ are independently of each other H, R′, (C1-C8)alkyl, (C1-C6)alkylene-R′, (C1-C6)alkylene-O—(C1-C6)alkyl, (C1-C6)alkylene-O—R′, (C1-C6)alkylene-CH[R′]2, (C1-C6)alkylene-C(O)—R′, (C1-C6)alkylene-C(O)NH2, (C1-C6)alkylene-C(O)NH—R′, or (C1-C6)alkylene-C(O)N[R′]2;
• R7 and R8 are independently of each other H, halogen, CN, NO2, (C1-C6)alkyl, O—(C1-C6)alkyl, (C2-C6)alkenyl, NH2, NH—SO2H, NH—SO2—(C1-C6)alkyl, SO2—NH2, NH—C(O)—(C1-C6)alkyl, C(O)N[(C1-C6)alkyl]2, C(O)OH, or C(O)O—(C1-C6)alkyl;
• R9 is halogen or (C1-C6)alkyl;
• R′ is (C3-C8)cycloalkyl, (C5-C10)heterocyclyl or (C6-C10)aryl;
• n is 0;
• and
• L is O or O—(C1-C6)alkylene;
• wherein
• in residues R4, R5, R7 and R8 one alkyl or alkylene hydrogen atom can optionally be substituted by OH, OCH3, COOH, COOCH3, NH2, NHCH3, N(CH3)2, CONH2, CONHCH3 or CON(CH3)2,
• or a pharmaceutically acceptable salt thereof, or a stereoisomeric form thereof, or a pharmaceutically acceptable salt of a stereoisomeric form thereof.