Erk1/2 posphorylation site specific antibody
AssigneeJulius-Maximilians-Universitaet Wuerzburg
InventorsMartin J. Lohse, Kristina Lorenz
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Abstract
The invention relates to an antibody specific to Erk1/2 phosphorylated at Thr188 and a method for producing the same. The invention also relates to an in vitro method for determining the presence of phosphorylated Erk1/2 in a sample using the antibody of the invention. Therefore, the invention also comprises an assay for diagnosing a heart disease in vitro comprising the antibody of the invention and certain uses of the antibody. Moreover the invention relates to a peptide used to produce the antibody.
Claims14
A purified phospho-specific antibody for Erk1/2 raised against a peptide consisting of SEQ ID NO:
- 1 wherein the Thr at position 8 of the sequence is phosphorylated, said antibody is specific to the peptide and does not cross-react with Erk phosphorylated at Thr183/Thr185.
A phospho-specific antibody for Erk1/2, obtained from a hybridoma, specific to a peptide consisting of SEQ ID NO:
- 1 wherein the Thr at position 8 of the sequence is phosphorylated, said antibody is specific to the peptide and does not cross-react with Erk phosphorylated at Thr183/Tyr 185.
Dependencies are inferred from the claim text.