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US 8,796,405 B2Granted
Degradable polycations derived from amino acid vinyl esters
OwnerMahesh Kalyana Mahanthappa, Glen Bradley Thomas +1inventors
InventorsMahesh Kalyana Mahanthappa, Glen Bradley Thomas, Corinne Elizabeth Lipscomb
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Abstract
Described herein are the synthesis and polymerization of a series of N-Boc-protected amino acid vinyl ester (BAAVE) monomers. Homopolymers and heteropolymers containing the monomers are described, particularly heteropolymers with vinyl ester monomers such as vinyl acetate. Deprotection can be used to produce hydrophilic and hydrophobic polymers that are particular useful in biological applications such as cellular delivery of biological materials.
Claims3
A polymer comprising units of the formula
- and salts thereof, wherein
- z is 0, 1, or 2, and
- R is H, a substituted or unsubstituted C1-C18 alkyl, a substituted or unsubstituted C2-C18 alkenyl, a substituted or unsubstituted C2-C18 alkynyl, a substituted or unsubstituted C3-C18 cycloalkyl, a substituted or unsubstituted C1-C18 haloalkyl, a substituted or unsubstituted C2-C18 heterocycloalkyl, a substituted or unsubstituted C6-C18 aryl, a substituted or unsubstituted C7-C18 arylalkylene, or a substituted or unsubstituted C3-C18 heteroaryl,
- R′ is H or R′ together with R forms a substituted or unsubstituted C2-C18 heterocycloalkyl, or substituted or unsubstituted C2-C18 heteroaryl group, each having 5 to 8 ring members.
1 more element
Dependencies are inferred from the claim text.