Antifouling hydrogels, coatings, and methods of synthesis and use thereof
AssigneeNorthwestern University
InventorsPhillip B. Messersmith, Jose Rivera, Yong-Kuang Gong
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Abstract
The invention provides an antifouling hydrogel comprising an effective amount of antifouling polymer modified with a compound containing catechol functional groups to yield a modified antifouling polymer comprising at least one catechol functional end group; and an effective amount of at least one oxidizing reagent, wherein the at least one oxidizing reagent reacts with the modified antifouling polymer to provide a modified antifouling polymer comprising at least one oxidized catechol end group, wherein an antifouling hydrogel is provided. Methods of synthesis, methods of use and kits of the antifouling hydrogel are also provided.
Claims13
An antifouling hydrogel resulting from the reaction between:
- a) an effective amount of a modified antifouling polymer having a structure according to Formula I:
- and
- b) an effective amount of at least one oxidizing reagent,
- whereby the antifouling hydrogel is formed.
A method of synthesizing an antifouling hydrogel comprising
- reacting a modified antifouling polymer having a structure according to Formula I:
- with at least one oxidizing agent;
- thereby providing an antifouling hydrogel.
A method of synthesizing an antifouling hydrogel that is immobilized on a surface comprising the steps of:
- a) reacting an effective amount of PEG with an effective amount of DOHA to yield a modified PEG having a structure according to Formula I:
- b) reacting an effective amount of Formula I with an effective amount of silver nitrate and NaIO4 in a 4:1 ethanol:water solution to provide a modified Formula I comprising oxidized catechol-end groups;
- and
- c) coating the modified Formula I comprising oxidized catechol-end groups to a surface, whereby the hydrogel formed is immobilized on the surface;
- thereby yielding an antifouling hydrogel that is immobilized on the surface.
Dependencies are inferred from the claim text.