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US 8,796,341 B2Granted
Pharmaceutical compositions providing enhanced drug concentrations
AssigneeBend Research, Inc.
InventorsWilliam J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
Life of this patent
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Abstract
A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
Claims8
A composition comprising:
- (a) a drug in a pharmaceutically acceptable solubility-improved form that is a suspension of said drug suspended in a liquid at a concentration that is at least 10-fold the equilibrium concentration of said drug in a use environment;
- and
- (b) an amphiphilic concentration-enhancing polymer;
- wherein said drug alone has an aqueous solubility of up to 2 mg/mL at pH 1 to 8.
1 more element
Dependencies are inferred from the claim text.