Biguanide compositions and methods of treating metabolic disorders
AssigneeElcelyx Therapeutics, Inc.
InventorsAlain D. Baron, Mark S. Fineman, Nigel R. A. Beeley
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Abstract
Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
Claims14
A method of ameliorating diabetes in a patient in need thereof comprising administering to the patient a pharmaceutical dosage form comprising a therapeutically effective amount of metformin or a salt thereof and having an onset of release in the duodenum, jejunum, ileum, caecum, colon and/or rectum of the subject, wherein the average systemic bioavailability of metformin as measured by plasma AUC resulting from administration of said pharmaceutical dosage form is 70%, 60%, 50%, 40%, 30% or 20% less than the average systemic bioavailability of an immediate release formulation having an equivalent amount of said metformin or salt thereof.
Dependencies are inferred from the claim text.